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Tg(RP23-326M22)760She
Transgene Detail
Nomenclature
Symbol: Tg(RP23-326M22)760She
Name: transgene insertion 760, Sarah Elsea
MGI ID: MGI:4461458
Synonyms: Rai1 BAC transgene, Rai1 transgene, TgRai1, Tg(RP23-326M22)1She
Transgene: Tg(RP23-326M22)760She  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL)F2 or C57BL/6J x (C57BL/6J x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(RP23-326M22)760She expresses 2 genes
 
Mutation detailsThis transgene consists of the C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-326M22 (GenBank id AC096624), which contains the entire coding sequence of the retinoic acid induced 1 (Rai1) gene. The BAC also includes the sterol regulator element binding transcription factor 1 gene (Srebf1; formerly Srebp1) and the 3' end of Tom1l2. Founder line 760 has integrated ~4 copies of the transgene at a single site. Overexpression of Rai1 in the brain and liver was verified by quantitative RT-PCR and western blot analysis. (J:161765)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
A second transgenic line generated using the same BAC was called Tg(RP23-326M22)775She (or Tg(RP23-326M22)2She). "All reported data were generated from the 760 line; however, the 775 line of mice showed similar results." (J:161765)
References
Original:  J:161765 Girirajan S, et al., How much is too much? Phenotypic consequences of Rai1 overexpression in mice. Eur J Hum Genet. 2008 Aug;16(8):941-54
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory