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Targeted Allele Detail
Symbol: Dp(10Prmt2-Pdxk)2Yey
Name: duplication, Chr 10, Y Eugene Yu 2
MGI ID: MGI:4461400
Synonyms: Dp(10)1Yey, Dp(10Prmt2-Pdxk)1Yey, Dp2Yey, Ts2Yey
Gene: Dp(10Prmt2-Pdxk)2Yey  Location: Chr10:76207227-78464975 bp  Genetic Position: Chr10, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:161325
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Not Applicable)
Mutation:    Duplication
  Dp(10Prmt2-Pdxk)2Yey involves 85 genes/genome features (Gm22441, Prmt2, Mir678 ...) View all
Mutation detailsCre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk results in duplication of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161325)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(10Prmt2-Pdxk)2Yey Mutation:  1 strain or line available
Original:  J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory