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Targeted Allele Detail
Symbol: Hsp90b1tm1.2Alee
Name: heat shock protein 90, beta (Grp94), member 1; targeted mutation 1.2, Amy Lee
MGI ID: MGI:4460991
Synonyms: Grp94-
Gene: Hsp90b1  Location: Chr10:86690209-86705509 bp, - strand  Genetic Position: Chr10, 43.05 cM
Embryonic lethality in Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:160900
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed and FRT flanked neomycin cassette was inserted in intron 1 and a third loxP site was inserted in intron 2. The neomycin cassette and exon 2 were subsequently removed by cre recombinase. (J:160900)
Generation of the Hsp90b1tm1.1Alee and Hsp90b1tm1.2Alee alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsp90b1 Mutation:  21 strains or lines available
Original:  J:160900 Mao C, et al., Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One. 2010;5(5):e10852
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory