Phenotypes associated with this allele

• Allele Symbol: Hsp90b1^tm1.2Alee
• Allele Name: targeted mutation 1.2, Amy Lee
• Allele ID: MGI:4460991
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsp90b1^tm1.2Alee/Hsp90b1^tm1.2Alee	involves: 129/Sv * C57BL/6J * FVB/N	MGI:4461007

Genotype
MGI:4461007

hm1

• Allelic Composition: Hsp90b1^tm1.2Alee/Hsp90b1^tm1.2Alee
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic lethality in Hsp90b1^tm1.2Alee/Hsp90b1^tm1.2Alee embryos

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:160900 )

• no homozygotes at birth

• embryos detectable at E3.5-E8.5

• homozygous embryos undetectable at E10.5 or later

embryo

decreased embryo size ( J:160900 )

• embryos much reduced in size at E7.5 and E8.5

disorganized embryonic tissue ( J:160900 )

• no recognizable embryonic structures at E7.5 and E8.5

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:160900 )

• ES cells derived from homozygous embryos are unable to differentiate intocardiomyocyte-like cells

growth/size/body

decreased embryo size ( J:160900 )

• embryos much reduced in size at E7.5 and E8.5