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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(ITK/SYK)Jrld
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jurgen Ruland
MGI ID: MGI:4460818
Synonyms: Rosa26loxSTOPlox-ITK-SYK
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Enlarged spleen in Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+ Tg(Cd4-cre)1Cwi/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:160931
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm1(ITK/SYK)Jrld expresses 2 genes
Mutation detailsA cDNA for the fusion of human ITK-SYK, which is preceded by a splice acceptor and floxed neo cassette and followed by an IRES-eGFP and polyadenylation sequence, was inserted into the locus. Cre mediated recombination is required to induce expression of the fusion cDNA. This fusion was identified peripheral T cell lymphoma patients with the chromosomal translocation t(5;9)(q33;p22). (J:160931)
Generation of the Gt(ROSA)26Sortm1(ITK/SYK)Jrld allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
Original:  J:160931 Pechloff K, et al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med. 2010 May 10;207(5):1031-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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