Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jurgen Ruland
• MGI ID: MGI:4460818
• Synonyms: Rosa26^{loxSTOPlox-ITK-SYK}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld} page

Enlarged spleen in Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺ Tg(Cd4-cre)1Cwi/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160931
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITK (3702)

  Itk	(MGI:96621)

  human

  SYK (6850)

  Syk	(MGI:99515)

• Mutation details: A cDNA for the fusion of human ITK-SYK, which is preceded by a splice acceptor and floxed neo cassette and followed by an IRES-eGFP and polyadenylation sequence, was inserted into the locus. Cre mediated recombination is required to induce expression of the fusion cDNA. This fusion was identified peripheral T cell lymphoma patients with the chromosomal translocation t(5;9)(q33;p22). (J:160931)

Generation of the Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:160931 Pechloff K, et al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med. 2010 May 10;207(5):1031-44
• All: 3 reference(s)