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Gt(ROSA)26Sortm1(ITK/SYK)Jrld
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(ITK/SYK)Jrld
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jurgen Ruland
MGI ID: MGI:4460818
Synonyms: Rosa26loxSTOPlox-ITK-SYK
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Enlarged spleen in Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+ Tg(Cd4-cre)1Cwi/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160931
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(ITK/SYK)Jrld expresses 2 genes
 
Mutation detailsA cDNA for the fusion of human ITK-SYK, which is preceded by a splice acceptor and floxed neo cassette and followed by an IRES-eGFP and polyadenylation sequence, was inserted into the locus. Cre mediated recombination is required to induce expression of the fusion cDNA. This fusion was identified peripheral T cell lymphoma patients with the chromosomal translocation t(5;9)(q33;p22). (J:160931)
Generation of the Gt(ROSA)26Sortm1(ITK/SYK)Jrld allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:160931 Pechloff K, et al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med. 2010 May 10;207(5):1031-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory