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Msh2tm2.2Rak
Targeted Allele Detail
Nomenclature
Symbol: Msh2tm2.2Rak
Name: mutS homolog 2; targeted mutation 2.2, Raju Kucherlapati
MGI ID: MGI:4460263
Synonyms: ECMsh2LoxP, Msh2delta12
Gene: Msh2  Location: Chr17:87672330-87723713 bp, + strand  Genetic Position: Chr17, 57.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161577
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exon 12 from Msh2tm2.1. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:161577)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:  69 strains or lines available
References
Original:  J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory