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Lmnatm6Lgf
Targeted Allele Detail
Nomenclature
Symbol: Lmnatm6Lgf
Name: lamin A; targeted mutation 6, Loren G Fong
MGI ID: MGI:4457608
Synonyms: LmnaPLAO
Gene: Lmna  Location: Chr3:88481148-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsIntrons 10 and 11 of Lmna were deleted thereby abolishing production of lamin C and producing only prelamin A. (J:160705)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  57 strains or lines available
References
Original:  J:160705 Davies BS, et al., An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 1;19(13):2682-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory