All Phenotypes Lmna<tm6Lgf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmna^tm6Lgf
targeted mutation 6, Loren G Fong
MGI:4457608

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm6Lgf/Lmna^tm6Lgf	involves: 129P2/OlaHsd	MGI:4840109
hm2	Lmna^tm6Lgf/Lmna^tm6Lgf	involves: 129P2/OlaHsd * C57BL/6	MGI:4457610
cx3	Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5754491
cx4	Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4457612
cx5	Lmna^tm6Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4457613

Allelic Composition	Lmna^tm6Lgf/Lmna^tm6Lgf
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm6Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:165928 )

• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice but less than in Lmna^tm7Lgf homozygotes

• nuclear stiffness in fibroblasts is increased compared to cells from wild-type mice and Lmna^tm7Lgf homozygotes

Allelic Composition	Lmna^tm6Lgf/Lmna^tm6Lgf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm6Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:160705 )

• body weight of females are slightly but significantly lower than those of wild-type females

Allelic Composition	Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm6Lgf mutation (0 available); any Lmna mutation (82 available)
Zmpste24^tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:220988 )

N	• mice do not exhibit intestinal abnormalities

Allelic Composition	Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:160705 )

• survival is worse than in Zmpste24 single mutants

premature death ( J:160705 )

• survival is worse than in Zmpste24 single mutants

growth/size/body

decreased body weight ( J:160705 )

• smaller than Zmpste24 single mutants

Allelic Composition	Lmna^tm6Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:160705 )

• survival is worse than in Zmpste24 single mutants

premature death ( J:160705 )

• survival is worse than in Zmpste24 single mutants

growth/size/body

decreased body weight ( J:160705 )

• smaller than Zmpste24 single mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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