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Targeted Allele Detail
Symbol: Pdcd1lg2tm4Shr
Name: programmed cell death 1 ligand 2; targeted mutation 4, Arlene H Sharpe
MGI ID: MGI:4456974
Synonyms: PDL1/L2
Gene: Pdcd1lg2  Location: Chr19:29410919-29471157 bp, + strand  Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:160970
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to replace the the IgV exon with a hygromycin resistance gene in ES cells containing the Cd274tm2Shr allele in which the CD274 antigen signal and two-thirds of the IgV exon were replaced with a neomycin cassette. (J:160970)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdcd1lg2 Mutation:  7 strains or lines available
Original:  J:160970 Sharpe A, Generation of PD-L1/PD-L2 mutant. MGI Direct Data Submission. 2010;
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory