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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdcd1lg2tm4Shr
targeted mutation 4, Arlene H Sharpe
MGI:4456974
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd274tm2Shr/Cd274tm2Shr
Pdcd1lg2tm4Shr/Pdcd1lg2tm4Shr 		involves: 129S4/SvJae MGI:4821796


Genotype
MGI:4821796
cx1
Allelic
Composition		 Cd274tm2Shr/Cd274tm2Shr
Pdcd1lg2tm4Shr/Pdcd1lg2tm4Shr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm2Shr mutation (2 available); any Cd274 mutation (36 available)
Pdcd1lg2tm4Shr mutation (1 available); any Pdcd1lg2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:160970 )
• mice are reported to exhibit a defect in T celll tolerance and increased immune activation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory