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Targeted Allele Detail
Symbol: Dusp4tm1Jmol
Name: dual specificity phosphatase 4; targeted mutation 1, Jeffery D Molkentin
MGI ID: MGI:4456264
Synonyms: Mkp2-
Gene: Dusp4  Location: Chr8:35274764-35287048 bp, + strand  Genetic Position: Chr8, 21.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:140567
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Not Specified
Mutation detailsExons 2 and 3 were replaced with a neomycin cassette via homologous recombination. RT-PCR confirmed the absence of transcript expression in the heart. (J:140567, J:200367)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dusp4 Mutation:  13 strains or lines available
Original:  J:140567 Ramesh S, et al., TGFbeta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep. 2008 Oct;9(10):990-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory