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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dusp4tm1Jmol
targeted mutation 1, Jeffery D Molkentin
MGI:4456264
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dusp4tm1Jmol/Dusp4tm1Jmol involves: 129 MGI:4456265


Genotype
MGI:4456265
hm1
Allelic
Composition		 Dusp4tm1Jmol/Dusp4tm1Jmol
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp4tm1Jmol mutation (1 available); any Dusp4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:140567 )
• bone marrow-derived, IL-7- dependent pro-B lymphocytes fail to exhibit a TGFbeta induced increased in apoptosis following a 24 or 48 hour treatment

cellular
decreased B cell apoptosis ( J:140567 )
• bone marrow-derived, IL-7- dependent pro-B lymphocytes fail to exhibit a TGFbeta induced increased in apoptosis following a 24 or 48 hour treatment

hematopoietic system
decreased B cell apoptosis ( J:140567 )
• bone marrow-derived, IL-7- dependent pro-B lymphocytes fail to exhibit a TGFbeta induced increased in apoptosis following a 24 or 48 hour treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory