Fshr^tm1Hht
Targeted Allele Detail

Summary

• Symbol: Fshr^tm1Hht
• Name: follicle stimulating hormone receptor; targeted mutation 1, Ilpo Huhtaniemi
• MGI ID: MGI:4456197
• Synonyms: Fshr^D580Y, mFshr^D580Y-ki
• Gene: Fshr Location: Chr17:89292380-89508103 bp, - strand Genetic Position: Chr17, 58.76 cM, cytoband E5
• Alliance: Fshr^tm1Hht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160015
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An aspartic acid to tyrosine substitution at residue 580 (D580Y) was introduced into exon 10, and a PKG-Neo fragment flanked by FRT sites was inserted into the downstream intron via homologous recombination. (J:160015)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fshr Mutation: 49 strains or lines available

References

• Original: J:160015 Peltoketo H, et al., Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Endocrinology. 2010 Apr;151(4):1872-83
• All: 1 reference(s)