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Exosc4tm1a(KOMP)Mbp
Targeted Allele Detail
Nomenclature
Symbol: Exosc4tm1a(KOMP)Mbp
Name: exosome component 4; targeted mutation 1a, Mouse Biology Program, UCDavis
MGI ID: MGI:4455390
Gene: Exosc4  Location: Chr15:76211597-76214870 bp, + strand  Genetic Position: Chr15, 35.72 cM
Mutation
origin
Mutant Cell Lines:  DEPD00523_2_A07, DEPD00523_2_A08, DEPD00523_2_B05, DEPD00523_2_B06, DEPD00523_2_B07, DEPD00523_2_B08, DEPD00523_2_C05, DEPD00523_2_C07, DEPD00523_2_C08, DEPD00523_2_D05, DEPD00523_2_D08, DEPD00523_2_E05, DEPD00523_2_E06, DEPD00523_2_E08, DEPD00523_2_F05, DEPD00523_2_F06, DEPD00523_2_F07, DEPD00523_2_F08, DEPD00523_2_G05, DEPD00523_2_G06, DEPD00523_2_G08, DEPD00523_2_H05, DEPD00523_2_H06, DEPD00523_2_H07, DEPD00523_2_H08
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 76212765 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 76214131. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Exosc4 Mutation:  9 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory