About   Help   FAQ
Hand2tm1.2Zllr
Targeted Allele Detail
Summary
Symbol: Hand2tm1.2Zllr
Name: heart and neural crest derivatives expressed 2; targeted mutation 1.2, Rolf Zeller
MGI ID: MGI:4453961
Synonyms: Hand2delta
Gene: Hand2  Location: Chr8:57774018-57777552 bp, + strand  Genetic Position: Chr8, 29.8 cM
Alliance: Hand2tm1.2Zllr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159210
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted to flank both coding exons. An frt-flanked pgk-neo cassette was included downstream of the 3' loxP site. Frt-mediated and Cre-mediated recombination removed the pgk-neo and deleted the transcription unit. (J:159210)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2 Mutation:  12 strains or lines available
References
Original:  J:159210 Galli A, et al., Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory