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Hand2tm1.2Zllr
Targeted Allele Detail
Nomenclature
Symbol: Hand2tm1.2Zllr
Name: heart and neural crest derivatives expressed 2; targeted mutation 1.2, Rolf Zeller
MGI ID: MGI:4453961
Synonyms: Hand2delta
Gene: Hand2  Location: Chr8:57320983-57324517 bp, + strand  Genetic Position: Chr8, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159210
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted to flank both coding exons. An frt-flanked pgk-neo cassette was included downstream of the 3' loxP site. Frt-mediated and Cre-mediated recombination removed the pgk-neo and deleted the transcription unit. (J:159210)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2 Mutation:  1 strain or line available
References
Original:  J:159210 Galli A, et al., Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory