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Cd4tm3.1Litt
Targeted Allele Detail
Nomenclature
Symbol: Cd4tm3.1Litt
Name: CD4 antigen; targeted mutation 3.1, Dan R Littman
MGI ID: MGI:4452050
Synonyms: Cd4E4pFL, E4PF
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158962
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change)
Mutation:    Insertion
 
Mutation detailsThe proximal enhancer upstream of exon 1 was flanked by a loxP site and a floxed neo cassette. Cre mediated recombination removed the neo cassette leaving the enhancer floxed. (J:158962)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
References
Original:  J:158962 Chong MM, et al., Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory