Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
N |
• CD4+ T cells activated in vitro with anti-CD3/CD28 antibodies and exposed to a cre adenovirus exhibit normal CD4 expression
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr112tm4.1Litt mutation
(0 available);
any
Rr112 mutation
(0 available)
Rr94tm3.1Litt mutation
(0 available);
any
Rr94 mutation
(0 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
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• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice
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• in the thymus and spleen
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hematopoietic system
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• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
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• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice
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• in the thymus and spleen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr94tm3.1Litt mutation
(0 available);
any
Rr94 mutation
(0 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
|
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
|
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
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• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
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• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
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hematopoietic system
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• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
|
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
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• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
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• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation
(1 available);
any
Cbfb mutation
(36 available)
Rr94tm3.1Litt mutation
(0 available);
any
Rr94 mutation
(0 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
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• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
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• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
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hematopoietic system
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• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
|
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
|
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
|
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
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immune system
N |
• mice exhibit normal CD4 expression during thymocyte development, in mature T cells, and splenic dendritic cells
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