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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr94tm3.1Litt
targeted mutation 3.1, Dan R Littman
MGI:4452050
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rr94tm3.1Litt/Rr94tm3.1Litt involves: 129P2/OlaHsd * FVB/N MGI:4452091
cn2
 		Rr94tm3.1Litt/Rr94+
Tg(Cd4-cre)1Cwi/0
Rr112tm4.1Litt/Rr112+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N MGI:4452095
cn3
 		Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:4452097
cn4
 		Cbfbtm1Itan/Cbfbtm1Itan
Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:4452098
cx5
 		Rr94tm3.1Litt/Rr94+
Rr112tm4.1Litt/Rr112+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N MGI:4452100


Genotype
MGI:4452091
cn1
Allelic
Composition		 Rr94tm3.1Litt/Rr94tm3.1Litt
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:158962 )
N
• CD4+ T cells activated in vitro with anti-CD3/CD28 antibodies and exposed to a cre adenovirus exhibit normal CD4 expression




Genotype
MGI:4452095
cn2
Allelic
Composition		 Rr94tm3.1Litt/Rr94+
Tg(Cd4-cre)1Cwi/0
Rr112tm4.1Litt/Rr112+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr112tm4.1Litt mutation (0 available); any Rr112 mutation (0 available)
Rr94tm3.1Litt mutation (0 available); any Rr94 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158962 )
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:158962 )
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice




Genotype
MGI:4452097
cn3
Allelic
Composition		 Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr94tm3.1Litt mutation (0 available); any Rr94 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:158962 )
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:158962 )
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice




Genotype
MGI:4452098
cn4
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (39 available)
Rr94tm3.1Litt mutation (0 available); any Rr94 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

hematopoietic system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice




Genotype
MGI:4452100
cx5
Allelic
Composition		 Rr94tm3.1Litt/Rr94+
Rr112tm4.1Litt/Rr112+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:158962 )
N
• mice exhibit normal CD4 expression during thymocyte development, in mature T cells, and splenic dendritic cells




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory