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Mfn2tm1.1Balo
Targeted Allele Detail
Nomenclature
Symbol: Mfn2tm1.1Balo
Name: mitofusin 2; targeted mutation 1.1, Robert Balo
MGI ID: MGI:4442975
Synonyms: Mfn2H361Y
Gene: Mfn2  Location: Chr4:147873599-147904704 bp, - strand  Genetic Position: Chr4, 78.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159219
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA floxed HA-tagged human cDNA with nucleotide substitutions that result in the amino acid substitution of tyrosine for histidine at position 361 (H361Y), GFP, and an frt flanked neo cassette were insered into exon 4, which contains the translation initiation site. Flp mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on E12.5 embryo extracts. (J:159219)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mfn2 Mutation:  20 strains or lines available
References
Original:  J:159219 Misko A, et al., Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J Neurosci. 2010 Mar 24;30(12):4232-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory