Muc2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Muc2^m2Btlr
• Name: mucin 2; mutation 2, Bruce Beutler
• MGI ID: MGI:4442897
• Synonyms: Muskatenwein
• Gene: Muc2 Location: Chr7:141276583-141308428 bp, + strand Genetic Position: Chr7, 87.1 cM, cytoband F5
• Alliance: Muc2^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation comprises a T to A transversion at nucleotide 2015 of the mRNA sequence (Genbank record XM_975612; base pair 148939344 on Chromosome 7, NCBI m37 mouse assembly (Build 37.1)). It results in replacement of isoleucine by asparagine at amino acid 672, in exon 44 of the gene's 47 coding exons (XM_975612). (J:159359) Additional incidental mutations were detected in sequencing for the causative mutation, Muc2^m2Btlr, and may be present in stocks carrying this mutation.
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc2 Mutation: 81 strains or lines available

References

• Original: J:159359 Brandl K, et al., Muskatenwein is an allele of Muc2 and confers susceptibility to DSS-induced colitis. MGI Direct Data Submission. 2010
• All: 1 reference(s)