Irf7^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf7^m1Btlr
• Name: interferon regulatory factor 7; mutation 1, Bruce Beutler
• MGI ID: MGI:4442855
• Synonyms: inept
• Gene: Irf7 Location: Chr7:140843096-140846412 bp, - strand Genetic Position: Chr7, 86.57 cM, cytoband F5
• Alliance: Irf7^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation comprises an A to G transition at nucleotide 749 of the mRNA sequence, in the fourth of the gene's 10 exons (Genbank record NM_016850; 148451039 bp on Chr 7, NCBI m37 mouse assembly (Build 37.1)). It results in replacement of aspartic acid by glycine at amino acid 110 (D110G), in the DNA-binding domain of the protein. (J:86521, J:159358) Additional incidental mutations were detected in sequencing for the causative mutation, Irf7^m1Btlr, and may be present in stocks carrying this mutation.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf7 Mutation: 23 strains or lines available

References

• Original: J:159358 Blasius A, et al., Inept is an allele of Irf7. MGI Direct Data Submission. 2010
• All: 5 reference(s)