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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf7m1Btlr
mutation 1, Bruce Beutler
MGI:4442855
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf7m1Btlr/Irf7m1Btlr C57BL/6J-Irf7m1Btlr MGI:4442856
ht2
 		Irf7m1Btlr/Irf7+ C57BL/6J-Irf7m1Btlr MGI:4442863


Genotype
MGI:4442856
hm1
Allelic
Composition		 Irf7m1Btlr/Irf7m1Btlr
Genetic
Background		 C57BL/6J-Irf7m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7m1Btlr mutation (1 available); any Irf7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:159358 )
• non-secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG
• reduced secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells in response to in vivo stimulation by resiquimod, a single-stranded (ss) RNA mimetic recognized by toll-like receptor 7 (TLR7)
decreased interferon-beta secretion ( J:159358 )
• non-secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG
• reduced secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells in response to in vivo stimulation by resiquimod, a single-stranded (ss) RNA mimetic recognized by toll-like receptor 7 (TLR7)




Genotype
MGI:4442863
ht2
Allelic
Composition		 Irf7m1Btlr/Irf7+
Genetic
Background		 C57BL/6J-Irf7m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7m1Btlr mutation (1 available); any Irf7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:159358 )
• reduced secretion of type I interferons (IFNalpha/IFNbeta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by resiquimod, a ss-RNA mimetic recognized by toll-like receptor 7 (TLR7)
• in contrast to the attenuated response of mice homozygous for this mutation, heterozygous mutant mice exhibit normal secretion of type I interferons by plasmacytoid dendritic cells in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG
decreased interferon-beta secretion ( J:159358 )
• reduced secretion of type I interferons (IFNalpha/IFNbeta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by resiquimod, a ss-RNA mimetic recognized by toll-like receptor 7 (TLR7)
• in contrast to the attenuated response of mice homozygous for this mutation, heterozygous mutant mice exhibit normal secretion of type I interferons by plasmacytoid dendritic cells in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory