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Fzd8tm1Nat
Targeted Allele Detail
Nomenclature
Symbol: Fzd8tm1Nat
Name: frizzled class receptor 8; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:4442631
Synonyms: Fz8lacZ
Gene: Fzd8  Location: Chr18:9212856-9216201 bp, + strand  Genetic Position: Chr18, 4.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159436
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame of the targeted gene was replaced by beta-galactosidase (LacZ) via homologous recombination in a 129-derived embryonic stem (ES) cell line. A PGK-neo selectable marker used for ES cell selection is present downstream of the LacZ sequences. (J:159436, J:170839)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd8 Mutation:  20 strains or lines available
References
Original:  J:159436 Nathans J, DDS for Fzd8. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory