All Phenotypes Fzd8<tm1Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fzd8^tm1Nat
targeted mutation 1, Jeremy Nathans
MGI:4442631

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzd8^tm1Nat/Fzd8^tm1Nat	involves: 129S1/Sv * 129X1/SvJ	MGI:4948324
cx2	Fzd4^tm1Nat/Fzd4^tm1Nat Fzd8^tm1Nat/Fzd8^tm1Nat	involves: 129S1/Sv * 129X1/SvJ	MGI:4948325
cx3	Fzd4^tm1Nat/Fzd4^tm1Nat Fzd8^tm1Nat/Fzd8⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:4948327

Allelic Composition	Fzd8^tm1Nat/Fzd8^tm1Nat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd8^tm1Nat mutation (1 available); any Fzd8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:170839 )

• mice are viable, normal sized, and fertile

Allelic Composition	Fzd4^tm1Nat/Fzd4^tm1Nat Fzd8^tm1Nat/Fzd8^tm1Nat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4^tm1Nat mutation (1 available); any Fzd4 mutation (31 available)
Fzd8^tm1Nat mutation (1 available); any Fzd8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:170839 )

• all mice die between E18.5 and P14

renal/urinary system

abnormal kidney development ( J:170839 )

• at E15.5, proliferation of epithelial cells within ureteric buds is decreased 1.8-fold compared to in wild-type mice

• however, cell proliferation in the rest of the developing kidney is normal

small kidney ( J:170839 )

• at E18.5

impaired branching involved in ureteric bud morphogenesis ( J:170839 )

• at E12.5

Allelic Composition	Fzd4^tm1Nat/Fzd4^tm1Nat Fzd8^tm1Nat/Fzd8⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

small kidney ( J:170839 )

• at E18.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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