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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fzd8tm1Nat
targeted mutation 1, Jeremy Nathans
MGI:4442631
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
\Fzd8tm1Nat/\Fzd8tm1Nat involves: 129S1/Sv * 129X1/SvJ MGI:4948324
cx2
\Fzd4tm1Nat/\Fzd4tm1Nat
\Fzd8tm1Nat/\Fzd8tm1Nat
involves: 129S1/Sv * 129X1/SvJ MGI:4948325
cx3
\Fzd4tm1Nat/\Fzd4tm1Nat
\Fzd8tm1Nat/\Fzd8+
involves: 129S1/Sv * 129X1/SvJ MGI:4948327


Genotype
MGI:4948324
hm1
Allelic
Composition
\Fzd8tm1Nat/\Fzd8tm1Nat
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd8tm1Nat mutation (1 available); any Fzd8 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable, normal sized, and fertile




Genotype
MGI:4948325
cx2
Allelic
Composition
\Fzd4tm1Nat/\Fzd4tm1Nat
\Fzd8tm1Nat/\Fzd8tm1Nat
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (31 available)
Fzd8tm1Nat mutation (1 available); any Fzd8 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• at E15.5, proliferation of epithelial cells within ureteric buds is decreased 1.8-fold compared to in wild-type mice
• however, cell proliferation in the rest of the developing kidney is normal
• at E18.5




Genotype
MGI:4948327
cx3
Allelic
Composition
\Fzd4tm1Nat/\Fzd4tm1Nat
\Fzd8tm1Nat/\Fzd8+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (31 available)
Fzd8tm1Nat mutation (1 available); any Fzd8 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• at E18.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory