Cdh23^tm1.2Ugds
Targeted Allele Detail

Summary

• Symbol: Cdh23^tm1.2Ugds
• Name: cadherin related 23 (otocadherin); targeted mutation 1.2, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:4441515
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^tm1.2Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158897
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 62 through 68. The absence of protein expression was confirmed by immunohistochemistry on cochlea samples. (J:158897)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 280 strains or lines available

References

• Original: J:158897 Etournay R, et al., Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape. Development. 2010 Apr;137(8):1373-83
• All: 4 reference(s)