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Tg(CAG-FCGRT)276Dcr
Transgene Detail
Nomenclature
Symbol: Tg(CAG-FCGRT)276Dcr
Name: transgene insertion 276, Derry C Roopenian
MGI ID: MGI:4441040
Synonyms: hFcRn (276) Tg, Tg276
Transgene: Tg(CAG-FCGRT)276Dcr  Location: Chr1:184861574-184861575 bp  Genetic Position: Chr1, Syntenic
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Duplication, Insertion
 
Tg(CAG-FCGRT)276Dcr expresses 1 gene
 
Mutation detailsTo generate the hFcRn line 276 transgenic mice, a transgene was designed with the 0.34 kb human cytomegalovirus immediate early promoter enhancer, 1.4 kb chicken beta-actin promoter and intron 1, a cDNA sequence encoding the human FcRn alpha-chain, 0.73 kb rabbit beta-globin intron, and 0.35 kb SV40 polyA sequence. Line 276 was established. Transgene insertion occurred on Chr 1, causing a 1 bp duplication. (J:110885)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
References
Original:  J:110885 Chaudhury C, et al., The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003 Feb 3;197(3):315-22
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory