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Dnajc6tm1Legr
Targeted Allele Detail
Nomenclature
Symbol: Dnajc6tm1Legr
Name: DnaJ heat shock protein family (Hsp40) member C6; targeted mutation 1, Lois Greene
MGI ID: MGI:4440489
Synonyms: Dnajc6tm1Pdc
Gene: Dnajc6  Location: Chr4:101353845-101499996 bp, + strand  Genetic Position: Chr4, 46.89 cM
Accumulation of clathrin-coated vesicles and clathrin cages at Dnajc6tm1Legr/Dnajc6tm1Legr synapses from deep cerebellar nuclei

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158574
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:158574)
Generation of the Dnajc6tm1Legr allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnajc6 Mutation:  34 strains or lines available
Notes
ES cell line = GSI
References
Original:  J:158574 Yim YI, et al., Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4412-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory