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Huwe1tm1Alas
Targeted Allele Detail
Nomenclature
Symbol: Huwe1tm1Alas
Name: HECT, UBA and WWE domain containing 1; targeted mutation 1, Anna Lasorella
MGI ID: MGI:4439480
Synonyms: Huwe1flox
Gene: Huwe1  Location: ChrX:151800807-151935417 bp, + strand  Genetic Position: ChrX, 68.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152966
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe allele was created by inserting an FRT-flanked pGKNeoR cassette into intron 82 and loxP sites into intron 79 and 82. Exons 80-82 encode most of the HECT domain of Huwe1. (J:145660)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Huwe1 Mutation:  53 strains or lines available
References
Original:  J:145660 Zhao X, et al., The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008 Jun;10(6):643-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory