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Targeted Allele Detail
Symbol: Adam10tm1.1Dhc
Name: a disintegrin and metallopeptidase domain 10; targeted mutation 1.1, Daniel H Conrad
MGI ID: MGI:4438892
Synonyms: AD10 fl, Adam10delta
Gene: Adam10  Location: Chr9:70678997-70780229 bp, + strand  Genetic Position: Chr9, 39.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:158127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 9, which encodes the Zinc-binding domain of the protease active site, was flanked by loxP sites. The Neo cassette was removed from the germline by FLP mediated recombination. (J:158127)
Generation of the Adam10tm1.1Dhc allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:  5 strains or lines available
Original:  J:158127 Gibb DR, et al., ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010 Mar 15;207(3):623-35
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory