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Adam10tm1.1Dhc
Targeted Allele Detail
Nomenclature
Symbol: Adam10tm1.1Dhc
Name: a disintegrin and metallopeptidase domain 10; targeted mutation 1.1, Daniel H Conrad
MGI ID: MGI:4438892
Synonyms: AD10 fl, Adam10delta
Gene: Adam10  Location: Chr9:70678997-70780229 bp, + strand  Genetic Position: Chr9, 39.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 9, which encodes the Zinc-binding domain of the protease active site, was flanked by loxP sites. The Neo cassette was removed from the germline by FLP mediated recombination. (J:158127)
Generation of the Adam10tm1.1Dhc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:  5 strains or lines available
References
Original:  J:158127 Gibb DR, et al., ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010 Mar 15;207(3):623-35
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory