| Image |
|
||||
| Caption | Generation of the Adam10tm1.1Dhc allele. A targeting vector containing intron 8, exon 9, and intron 9 of mouse Adam10 , and loxP (gray triangles) and FRT (open triangles) sites were inserted into the Adam10 gene via homologous recombination to generate an ADAM10 flox allele. Removal of the Neo cassette via Flp1-mediated recombination generated Adam10tm1.1Dhc (ADAM10delta), containing exon 9 flanked by loxP sites. Cre-mediated recombination can be used to conditionally remove exon 9. Primers P1 and P2 amplify a 955-bp sequence of nonrecombined ADAM10delta or a 217-bp sequence of the recombined allele, respectively. | ||||
| Copyright | This image is from Gibb DR, J Exp Med 2010 Mar 15;207(3):623-35, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:158127 | ||||
|
Associated Alleles |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools