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Targeted Allele Detail
Symbol: Dnm1ltm1.1Miha
Name: dynamin 1-like; targeted mutation 1.1, Katsuyoshi Mihara
MGI ID: MGI:4438630
Synonyms: Drp1lox
Gene: Dnm1l  Location: Chr16:16312230-16358959 bp, - strand  Genetic Position: Chr16, 10.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:158142
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:158142)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnm1l Mutation:  10 strains or lines available
Original:  J:158142 Ishihara N, et al., Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009 Aug;11(8):958-66
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory