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Tg(tetO-CUGBP1)3413Coop
Transgene Detail
Nomenclature
Symbol: Tg(tetO-CUGBP1)3413Coop
Name: transgene insertion 3413, Thomas A Cooper
MGI ID: MGI:4438033
Synonyms: TRECUGBP1
Transgene: Tg(tetO-CUGBP1)3413Coop  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-CUGBP1)3413Coop expresses 1 gene
 
Mutation detailsThe tetracycline-responsive element and minimal CMV promoter drives expression of the FLAG-tagged LYLQ isoform of the human cDNA preceded by a genomic fragment containing the untranslated exons 2 and 3 with intron 2 of Myh6 and followed by a bovine hormone polyadenylation site and 3' flanking genomic sequence. Three lines were created (including lines 3413 and 3481). Line 3413 exhibit a 4- to 8-fold induction of exogenous protein expression. (J:157646)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:157646 Koshelev M, et al., Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15;19(6):1066-75
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory