Ptk2^tm1Heen
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1Heen
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen
• MGI ID: MGI:4437305
• Synonyms: FAK^delta
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1Heen page

Hemorrhages, edemas, abnormal heart, lung, liver and limb development, and delayed artery formation and vascular remodeling defects in Ptk2^tm1Heen/Ptk2^tm1Heen embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157804
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutations: Insertion, Intragenic deletion Mutation details: The targeting vector replaced alternative exons 13 and 14 with an frt flanked hygro cassette and floxed the alternative exon 16. A spontaneous deletion of 307 bp removed exon 15. This deletion is expected to produce a protein lacking the autophosphorylation site tyrosine 397. Production of a truncated protein was confirmed by western blot analysis. (J:157804)

Generation of the Ptk2^tm1Heen allele

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 90 strains or lines available

References

• Original: J:157804 Corsi JM, et al., Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76
• All: 1 reference(s)