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Targeted Allele Detail
Symbol: Nfatc2iptm1.1Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein; targeted mutation 1.1, Laurie Glimcher
MGI ID: MGI:4437260
Synonyms: Nip45-
Gene: Nfatc2ip  Location: Chr7:126382854-126396737 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F4
Germline Transmission:  Earliest citation of germline transmission: J:157559
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 and 2 were deleted and replaced with a floxed neomycin cassette. The selection cassette was removed by cre mediated recombination. RNA and protein absence were confirmed by northern and western blotting, respectively. Absence of expression did not alter the stability of its binding partners, NFATC1, NFATC2, and NFATC3 (J:157559)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc2ip Mutation:  127 strains or lines available
Original:  J:157559 Fathman JW, et al., NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3663-8
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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