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Nfatc2iptm1.1Glm
Targeted Allele Detail
Nomenclature
Symbol: Nfatc2iptm1.1Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein; targeted mutation 1.1, Laurie Glimcher
MGI ID: MGI:4437260
Synonyms: Nip45-
Gene: Nfatc2ip  Location: Chr7:126382854-126396737 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157559
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and 2 were deleted and replaced with a floxed neomycin cassette. The selection cassette was removed by cre mediated recombination. RNA and protein absence were confirmed by northern and western blotting, respectively. Absence of expression did not alter the stability of its binding partners, NFATC1, NFATC2, and NFATC3 (J:157559)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc2ip Mutation:  124 strains or lines available
References
Original:  J:157559 Fathman JW, et al., NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3663-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory