Adissp^{tm1a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Adissp^{tm1a(EUCOMM)Hmgu}
• Name: adipose secreted signaling protein; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:4435368
• Gene: Adissp Location: Chr2:130988244-131002001 bp, - strand Genetic Position: Chr2, 63.28 cM, cytoband F3
• Alliance: Adissp^{tm1a(EUCOMM)Hmgu} page
• IMPC: Adissp gene page

Mutation origin

• Mutant Cell Lines: HEPD0500_2_A02, HEPD0500_2_A03, HEPD0500_2_B01, HEPD0500_2_B02, HEPD0500_2_B03, HEPD0500_2_C01, HEPD0500_2_C02, HEPD0500_2_C03, HEPD0500_2_D01, HEPD0500_2_D02, HEPD0500_2_E01, HEPD0500_2_E02, HEPD0500_2_E03, HEPD0500_2_F02, HEPD0500_2_G01, HEPD0500_2_G02, HEPD0500_2_H01, HEPD0500_2_H03
• Germline Transmission: Earliest citation of germline transmission: J:332979
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 130993292 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 130994101. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065, J:332979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adissp Mutation: 23 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 2 reference(s)