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Targeted Allele Detail
Symbol: Arid2tm1a(EUCOMM)Wtsi
Name: AT rich interactive domain 2 (ARID, RFX-like); targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4433303
Synonyms: BAF200LacZ
Gene: Arid2  Location: Chr15:96185399-96302873 bp, + strand  Genetic Position: Chr15, 52.37 cM, cytoband F2
Mutant Cell Lines:  EPD0027_2_A04, EPD0027_2_B04, EPD0027_2_B05, EPD0027_2_B06, EPD0027_2_C04, EPD0027_2_C06, EPD0027_2_E04, EPD0027_2_E05, EPD0027_2_E06, EPD0027_2_F04, EPD0027_2_F05, EPD0027_2_F06, EPD0027_2_G04, EPD0027_2_G05, EPD0027_2_H04, EPD0027_2_H05, EPD0027_2_H06
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
Mutation detailsThe L1L2_gt2 cassette was inserted at position 96247446 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 96248256. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534, J:223458)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Arid2 Mutation:  69 strains or lines available
Cell line EPD0027_2_B05 was successfully used to make chimeric mice. Germline transmission was accomplished. J:223458
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory