Phenotypes associated with this allele

• Allele Symbol: Arid2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433303
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid2^tm1a(EUCOMM)Wtsi/Arid2^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Arid2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6261904
hm2	Arid2^tm1a(EUCOMM)Wtsi/Arid2^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5751305

Genotype
MGI:6261904

hm1

• Allelic Composition: Arid2^{tm1a(EUCOMM)Wtsi}/Arid2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Arid2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0027_2_B05

Data Sources

IMPC Data for Arid2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5751305

hm2

• Allelic Composition: Arid2^{tm1a(EUCOMM)Wtsi}/Arid2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0027_2_B05

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:223458 )

• mice die between E12.5 and E14.5

cardiovascular system

cardiovascular system phenotype ( J:223458 )

N • blood vessel development in the brain and liver is normal

abnormal coronary artery morphology ( J:223458 )

• reduced number

abnormal angiogenesis ( J:223458 )

• reduced intramyocardial coronary vascular endothelial cells

thin myocardium compact layer ( J:223458 )

double outlet right ventricle ( J:223458 )

abnormal atrioventricular valve morphology ( J:223458 )

common atrioventricular valve ( J:223458 )

inlet ventricular septal defect ( J:223458 )

abnormal cardiovascular system physiology ( J:223458 )

• suggested by subcutaneous edema and hemorrhage at E14.5

hemorrhage ( J:223458 )

• at E14.5

decreased fetal cardiomyocyte proliferation ( J:223458 )

• without an increase in cell death

homeostasis/metabolism

subcutaneous edema ( J:223458 )

• at E14.5

immune system

immune system phenotype ( J:223458 )

N • lymphatic vessel development is normal

cellular

decreased fetal cardiomyocyte proliferation ( J:223458 )

• without an increase in cell death

muscle

thin myocardium compact layer ( J:223458 )

decreased fetal cardiomyocyte proliferation ( J:223458 )

• without an increase in cell death

integument

subcutaneous edema ( J:223458 )

• at E14.5