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Tg(Emu-TXLNA)1Amjr
Transgene Detail
Nomenclature
Symbol: Tg(Emu-TXLNA)1Amjr
Name: transgene insertion 1, Julian Ambrus Jr
MGI ID: MGI:4430747
Synonyms: IL-14alpha Tg, pEuSR-IL-14alpha
Transgene: Tg(Emu-TXLNA)1Amjr  Location: unknown  Genetic Position: Chr18, Syntenic
Transgene
origin
Strain of Origin:  (C3H x C57BL/6J)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Emu-TXLNA)1Amjr expresses 1 gene
 
Mutation detailsThe pEmuSR-IL-14alpha transgene was designed with the Emu immunoglobulin heavy chain enhancer/SV40 promoter regions (from the pEmuSR vector) upstream of a hemagglutinin-tagged human IL-14alpha (TXLNA or taxilin alpha) cDNA sequence (human IL-14alpha is a cytokine encoded by the plus strand of the IL-14 gene using exons 3-10). FISH analysis showed positive immunofluorescence on chromosome 18. (J:117018)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:117018 Shen L, et al., Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol. 2006 Oct 15;177(8):5676-86
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory