Cmklr1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Cmklr1^tm1Dgen
• Name: chemerin chemokine-like receptor 1; targeted mutation 1, Deltagen
• MGI ID: MGI:4430512
• Gene: Cmklr1 Location: Chr5:113750415-113788487 bp, - strand Genetic Position: Chr5, 55.55 cM, cytoband F
• Alliance: Cmklr1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157190
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette was inserted in the third exon, replacing codons 55 to 104, by homologous recombination. No protein was detectable by FACS and immunohistochemistry. (J:157190)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cmklr1 Mutation: 46 strains or lines available

References

• Original: J:157190 Luangsay S, et al., Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model. J Immunol. 2009 Nov 15;183(10):6489-99
• All: 18 reference(s)