Phenotypes associated with this allele

• Allele Symbol: Cmklr1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4430512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cmklr1^tm1Dgen/Cmklr1^tm1Dgen	B6.Cg-Cmklr1^tm1Dgen	MGI:4430513

Genotype
MGI:4430513

hm1

• Allelic Composition: Cmklr1^tm1Dgen/Cmklr1^tm1Dgen
• Genetic Background: B6.Cg-Cmklr1^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:157190 )

increased neutrophil cell number ( J:157190 )

• lipopolysaccharide induces a stronger inflammatory response with an increase of neutrophils in bronchoalveolar lavage fluids and lung cell suspensions

abnormal alveolar macrophage morphology ( J:157190 )

• lower proportion of F4/80+CD11c+ alveolar macrophages following lipopolysaccharide treatment

abnormal professional antigen presenting cell physiology ( J:157190 )

abnormal macrophage chemotaxis ( J:157190 )

• macrophage recruitment by lipopolysaccharide is higher in bronchoalveolar lavage fluids and total lungs

abnormal dendritic cell physiology ( J:157190 )

• bone marrow dendritic cells fail to migrate in response to chemerin

• however, migration in response to CCL5 and CXCL12 is normal

increased susceptibility to endotoxin shock ( J:157190 )

• lipopolysaccharide induces a stronger inflammatory response with an increase of neutrophils in bronchoalveolar lavage fluids and lung cell suspensions

lung inflammation ( J:157190 )

• lipopolysaccharide induces a stronger inflammatory response with an increase of neutrophils in bronchoalveolar lavage fluids and lung cell suspensions

• chemerin treatment has no effect on inflammatory cytokines and chemokines in bronchoalveolar lavages

respiratory system

abnormal alveolar macrophage morphology ( J:157190 )

• lower proportion of F4/80+CD11c+ alveolar macrophages following lipopolysaccharide treatment

lung inflammation ( J:157190 )

• lipopolysaccharide induces a stronger inflammatory response with an increase of neutrophils in bronchoalveolar lavage fluids and lung cell suspensions

• chemerin treatment has no effect on inflammatory cytokines and chemokines in bronchoalveolar lavages

hematopoietic system

abnormal macrophage chemotaxis ( J:157190 )

• macrophage recruitment by lipopolysaccharide is higher in bronchoalveolar lavage fluids and total lungs

abnormal definitive hematopoiesis ( J:157190 )

increased neutrophil cell number ( J:157190 )

• lipopolysaccharide induces a stronger inflammatory response with an increase of neutrophils in bronchoalveolar lavage fluids and lung cell suspensions

abnormal alveolar macrophage morphology ( J:157190 )

• lower proportion of F4/80+CD11c+ alveolar macrophages following lipopolysaccharide treatment

cellular

abnormal macrophage chemotaxis ( J:157190 )

• macrophage recruitment by lipopolysaccharide is higher in bronchoalveolar lavage fluids and total lungs