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Targeted Allele Detail
Symbol: Irs1tm2.1Mfw
Name: insulin receptor substrate 1; targeted mutation 2.1, Morris F White
MGI ID: MGI:4430350
Synonyms: IRS1a
Gene: Irs1  Location: Chr1:82233101-82291416 bp, - strand  Genetic Position: Chr1, 42.0 cM, cytoband C5
Germline Transmission:  Earliest citation of germline transmission: J:156999
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA point mutation changing Ser 307 to Ala (S307A) and a floxed Neo cassette placed immediately after the stop codon were inserted by homologous recombination. The neo has been removed by cre-mediated recombination. A residual 66 bp, includes a loxP site, remains in the 3' UTR. (J:156999)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs1 Mutation:  20 strains or lines available
Original:  J:156999 Copps KD, et al., Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010 Jan;11(1):84-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory