Hipk2^tm1Afus
Targeted Allele Detail

Summary

• Symbol: Hipk2^tm1Afus
• Name: homeodomain interacting protein kinase 2; targeted mutation 1, Alfredo Fusco
• MGI ID: MGI:4429497
• Gene: Hipk2 Location: Chr6:38671325-38853099 bp, - strand Genetic Position: Chr6, 17.85 cM, cytoband B
• Alliance: Hipk2^tm1Afus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156574
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.5 kb region containing exon 3 was replaced by an IRES-LacZ-Neo cassette by homologous recombination. RT-PCR of liver mRNA confirmed absence of transcript. (J:156574)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hipk2 Mutation: 53 strains or lines available

References

• Original: J:156574 Trapasso F, et al., Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro. DNA Cell Biol. 2009 Apr;28(4):161-7
• All: 5 reference(s)