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Targeted Allele Detail
Symbol: Hipk2tm1Afus
Name: homeodomain interacting protein kinase 2; targeted mutation 1, Alfredo Fusco
MGI ID: MGI:4429497
Gene: Hipk2  Location: Chr6:38694390-38876165 bp, - strand  Genetic Position: Chr6, 17.85 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:156574
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 5.5 kb region containing exon 3 was replaced by an IRES-LacZ-Neo cassette by homologous recombination. RT-PCR of liver mRNA confirmed absence of transcript. (J:156574)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hipk2 Mutation:  9 strains or lines available
Original:  J:156574 Trapasso F, et al., Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro. DNA Cell Biol. 2009 Apr;28(4):161-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory