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Kdrtm1Wag
Targeted Allele Detail
Nomenclature
Symbol: Kdrtm1Wag
Name: kinase insert domain protein receptor; targeted mutation 1, Erwin F Wagner
MGI ID: MGI:4422101
Synonyms: Flk1lox, Flk1loxP, Vegfr2lox
Gene: Kdr  Location: Chr5:75932827-75978458 bp, - strand  Genetic Position: Chr5, 40.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86207
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an frt floxed neo cassette was inserted downstream of exon 1. (J:86207, J:156986)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:  10 strains or lines available
References
Original:  J:86207 Haigh JJ, et al., Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol. 2003 Oct 15;262(2):225-41
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory