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Tdrd9tm1.1Chum
Targeted Allele Detail
Nomenclature
Symbol: Tdrd9tm1.1Chum
Name: tudor domain containing 9; targeted mutation 1.1, Shinichiro Chuma
MGI ID: MGI:4421849
Synonyms: Tdrd9-
Gene: Tdrd9  Location: Chr12:111971559-112068854 bp, + strand  Genetic Position: Chr12, 61.14 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156018
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3, and a pgk-neo cassette flanked by FRT sites as well as a second loxP site were targeted downstream of exon 7. Chimeric mice were produced from two recombinant ES cell clones. Exons 3-7 were excised by Cre mediated recombination. Western blot, immunostaining and RT-PCR showed no protein or RNA were detectable in the mutant testis. (J:156018)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tdrd9 Mutation:  28 strains or lines available
References
Original:  J:156018 Shoji M, et al., The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009 Dec;17(6):775-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory