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Igh-Jtm1.1Lave
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1.1Lave
Name: immunoglobulin heavy chain, joining region; targeted mutation 1.1, Laurent Verkoczy
MGI ID: MGI:4421672
Synonyms: 2f5, 2F5 VH+, Igh-Jtm1.1(2F5)Lave
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155798
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe human monoclonal antibody 2F5 was targeted into the J region removing J1 through 4 to produce chimeric human/mouse 2F5 antibodies. A floxed neo cassette used for ES cell selection was removed by cre mediated recombination. The 2F5 antibody is a polyreactive and broadly neutralizing antibody that protects against simian HIV challenge. (J:155798)
Generation of the Igh-Jtm1.1Lave allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:155798 Verkoczy L, et al., Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):181-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory