Tardbptm1.1Ckjs
Targeted Allele Detail
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Symbol: |
Tardbptm1.1Ckjs |
Name: |
TAR DNA binding protein; targeted mutation 1.1, C K James Shen |
MGI ID: |
MGI:4418700 |
Gene: |
Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
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Alliance: |
Tardbptm1.1Ckjs page
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Tardbptm1.1Ckjs/Tardbptm1.1Ckjs embryos show defective development of the inner cell mass in vitro
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:155958
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2 and 3 were flanked by lox sites and an FRT flanked neo cassette and a 29 bp deletion for genotyping were inserted in intron 3 via homologous recombination. Cre mediated recombination removed the selection cassette and exons including the translational start site. Protein was undetectable by immunofluorescence after E3.5.
(J:155958)
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Generation of the Tardbptm1Ckjs and Tardbptm1.1Ckjs alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tardbp Mutation: |
60 strains or lines available
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Original: |
J:155958 Wu LS, et al., TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010 Jan;48(1):56-62 |
All: |
2 reference(s) |
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