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Tg(KRT14-Fyn*)aJsey
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-Fyn*)aJsey
Name: transgene insertion a, John Seykora
MGI ID: MGI:4417930
Synonyms: K14-Fyn Y528F, Tg(Krt14-Fyn*)1Jsey
Transgene: Tg(KRT14-Fyn*)aJsey  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT14-Fyn*)aJsey expresses 1 gene
 
Mutation detailsMurine FynY528F cDNA was inserted downstream of the human keratin 14 promoter. Two independent lines with hyperkeratotic plaques and tumor phenotype were derived. Line a was generated. (J:155536)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:155536 Zhao L, et al., Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53. Cancer Res. 2009 Dec 15;69(24):9439-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory