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Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Name: transgene insertion 10, TaconicArtemis
MGI ID: MGI:4417910
Synonyms: ARTE10, Tg(Thy1-PSEN1*M146V/Thy1-APP*swe)10Arte
Transgene: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte expresses 2 genes
 
Mutation detailsThis transgene is composed of two constructs containing the Thy1 promoter driving expression of human PSEN1 with the amino acid substitution of valine for methionine at position 146 and human APP with the Swedish familial Alzheimer disease mutation (K670N, M671L). Line 10 (also known as 10-279) was selected as the representative line. (J:155410)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:155410 Willuweit A, et al., Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS One. 2009;4(11):e7931
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory