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Nfkb2Lym1
Chemically induced Allele Detail
Nomenclature
Symbol: Nfkb2Lym1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Lym1
MGI ID: MGI:4412046
Gene: Nfkb2  Location: Chr19:46304320-46312385 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Mutation
origin
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsAn ENU mutation resulted in a T to A transversion at base 2854 in the genomic DNA. The mutation is predicted to replace the codon that encodes amino acid 868 with a premature stop codon. The reduced protein size was confirmed by western blot. (J:154812)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:  38 strains or lines available
References
Original:  J:154812 Tucker E, et al., A novel mutation in the Nfkb2 gene generates an NF-kappa B2 'super repressor'. J Immunol. 2007 Dec 1;179(11):7514-22
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory