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Targeted Allele Detail
Symbol: Kcnq3tm1.1Naas
Name: potassium voltage-gated channel, subfamily Q, member 3; targeted mutation 1.1, Nanda A Singh
MGI ID: MGI:4397593
Synonyms: Kcnq3G311V
Gene: Kcnq3  Location: Chr15:65986387-66286642 bp, - strand  Genetic Position: Chr15, 29.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:154582
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA self-excising neo cassette was inserted upsteam of exon 7. Exon 5 contains nucleotide substitutions that result in the amino acid substitution of valine for glycine at position 311 (G311V). The neo cassette subsequently removes itself leaving a single loxP site. (J:154582)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq3 Mutation:  40 strains or lines available
Original:  J:154582 Singh NA, et al., Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15;586(14):3405-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory