All Phenotypes Kcnq3<tm1.1Naas> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnq3^tm1.1Naas
targeted mutation 1.1, Nanda A Singh
MGI:4397593

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas	B6.129-Kcnq3^tm1.1Naas	MGI:4397675
hm2	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas	FVB.129-Kcnq3^tm1.1Naas	MGI:4397677
hm3	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4397673
hm4	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4397676
ht5	Kcnq3^tm1.1Naas/Kcnq3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4397674
ht6	Kcnq3^tm1.1Naas/Kcnq3⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4397678

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas
Genetic Background	B6.129-Kcnq3^tm1.1Naas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:154582 )

• fewer than expected mice were born

nervous system

seizures ( J:154582 )

• mice exhibit rare spontaneous seizures

• 50% of mice exhibit a single severe seizures between weaning and P72

growth/size/body

decreased body size ( J:154582 )

behavior/neurological

seizures ( J:154582 )

• mice exhibit rare spontaneous seizures

• 50% of mice exhibit a single severe seizures between weaning and P72

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas
Genetic Background	FVB.129-Kcnq3^tm1.1Naas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:154582 )

• after P15, mice exhibit increased mortality compared with wild-type mice

• 20% of mice die during or after a spontaneous seizure

neonatal lethality, incomplete penetrance ( J:154582 )

• some mice die at P0

nervous system

nervous system phenotype ( J:154582 )

N	• despite seizures, mice exhibit no hippocampal mossy fiber sprouting or neuronal loss

seizures ( J:154582 )

• mice exhibit spontaneous seizures as early as the second postnatal week unlike wild-type mice

• after weaning, mice exhibit multiple spontaneous recurrent seizures unlike wild-type mice

• at P30 to P45, mice exhibit a decline in seizure severity

• by P65 to P75, mice exhibit low grade seizures with bilateral forelimb clonus, orofacial automatisms, jaw chomping, head clonus, occasional falling, and rearing

• clusters of seizures increase with age while severity decreases

astrocytosis ( J:154582 )

• in multiple hippocampal regions at P32 and P120

abnormal hippocampus morphology ( J:154582 )

• after recurrent seizures, mice exhibit selected regions of necrosis in the hippocampus unlike in wild-type mice

growth/size/body

decreased body size ( J:154582 )

behavior/neurological

seizures ( J:154582 )

• mice exhibit spontaneous seizures as early as the second postnatal week unlike wild-type mice

• after weaning, mice exhibit multiple spontaneous recurrent seizures unlike wild-type mice

• at P30 to P45, mice exhibit a decline in seizure severity

• by P65 to P75, mice exhibit low grade seizures with bilateral forelimb clonus, orofacial automatisms, jaw chomping, head clonus, occasional falling, and rearing

• clusters of seizures increase with age while severity decreases

cellular

astrocytosis ( J:154582 )

• in multiple hippocampal regions at P32 and P120

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:154582 )

• fewer than expected mice were born

nervous system

seizures ( J:154582 )

• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice

abnormal neuron physiology ( J:154582 )

• CA1 neurons exhibit decreased M-type potassium ion current amplitude and density compared with wild-type neurons

behavior/neurological

seizures ( J:154582 )

• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3^tm1.1Naas
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:154582 )

• fewer than expected mice were born

nervous system

abnormal neuron physiology ( J:154582 )

• CA1 neurons exhibit decreased M-type potassium ion current amplitude and density compared with wild-type neurons

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:154582 )

• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice

nervous system

abnormal seizure response to electrical stimulation ( J:154582 )

• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582

Allelic Composition	Kcnq3^tm1.1Naas/Kcnq3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq3^tm1.1Naas mutation (0 available); any Kcnq3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:154582 )

• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice

nervous system

abnormal seizure response to electrical stimulation ( J:154582 )

• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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